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Undercover Agents Fight Autoimmunity

Thu, 11/13/2008 - 12:41
Categories: PLoS

For New Neurons in an Old Brain, cdk5 Shows the Way

Thu, 11/13/2008 - 12:41
Categories: PLoS

S-Nitrosylation of Surfactant Protein-D Controls Inflammatory Function

Thu, 11/13/2008 - 12:41
Nitric oxide is shown to control the pro- and anti-inflammatory functions of surfactant protein D by altering its quaternary structure via S-nitrosylation.
Categories: PLoS

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus

Thu, 11/13/2008 - 12:41
New neurons are born throughout life in the hippocampus. Cell-type-specific, single-gene ablation in newborn neurons reveals that the kinase cdk5 regulates growth of neuronal processes, identifying a key mechanism of neuronal integration within the adult brain.
Categories: PLoS

Specific Immunosuppression with Inducible Foxp3-Transduced Polyclonal T cells

Thu, 11/13/2008 - 12:41
An approach to induce specific tolerance--an important application for the treatment of autoimmune diseases and transplant rejections--uses polyclonal T cells transduced with an inducible form of Foxp3.
Categories: PLoS

Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome

Thu, 11/13/2008 - 12:41
Transcription from within open reading frames in S. cerevisiae, which is normally repressed by many chromatin- and transcription-related factors, has the potential to be widespread and to express alternative genetic information.
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Redefining “Natural” in Agriculture

Mon, 08/25/2008 - 08:18
Can organic farming and genetically engineered crops coexist in an agriculture of the future? Tony Trewavas reviews the new book Tomorrow's Table.
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The Thief in the Mirror

Mon, 08/25/2008 - 08:18
The few animals capable of recognizing themselves in a mirror have advanced social cognition related to adopting the perspective of someone else.
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Mirror-Induced Behavior in the Magpie (Pica pica): Evidence of Self-Recognition

Mon, 08/25/2008 - 08:18
The European magpie, a bird with a large brain and highly developed perspective-taking skills, shows evidence of mirror self-recognition.
Categories: PLoS

The NDR/LATS Family Kinase Cbk1 Directly Controls Transcriptional Asymmetry

Mon, 08/25/2008 - 08:18
A conserved protein kinase, Cbk-1, produces different gene expression programs in cytoplasmically connected cells by directly blocking nuclear export of the transcription factor Ace2.
Categories: PLoS

Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster

Mon, 08/25/2008 - 08:18
We show that the mitochondrial DNA mutation rate in D. melanogaster is 10X higher than the nuclear mutation rate, and that major-strand G-->A hypermutablity explains the extremely biased base composition of the mitochondrial genome.
Categories: PLoS