West Africa Doctors Network News Portal

The PLoS Medicine Editors discuss the requirements in the 2007 Food and Drug Administration Amendments Act for reporting of clinical trials results, and the role of journals.

Cynthia Aaron discusses the possible clinical implications of a new study evaluating electrophysiological changes in a cohort of patients with organophosphate poisoning.

Jayawardane and colleagues evaluate a cohort of 78 patients with organophosphate poisoning from Sri Lanka, and identify changes in repetitive nerve stimulation that precede, and may help predict, the onset of intermediate syndrome.

In a systematic review and meta-analysis including more than 17,000 tuberculosis cases, Christie Jeon and Megan Murray find that diabetes mellitus is associated with an approximately 3-fold increased risk of tuberculosis.

Using reduced-impact timber-harvesting practices in legally logged tropical forests would reduce global carbon emissions by 0.16 Gt/year at a modest cost and with little risk of "leakage" (increased carbon emissions elsewhere).

In leaves, cells get larger as cell division decreases or the ploidy increases. This might seem a logical response, but the controls are more complicated.

The development of a short-time scale colloidal system introduces flow cytometry as a tool to investigate both physicochemical and molecular aspects of bacterial adhesion to solid surfaces.

Satellite tracking data from female leatherback turtles reveal their migration routes in the eastern Pacific and demonstrate how oceanic currents shape their migration corridors, providing a biological basis for conservation strategies.

Controversy surrounds the glycolipid iGb3. Our data show that humans do not express this lipid. This has important implications in natural killer T cell development, self-recognition, and transplantation.

Nicholas White and colleagues discuss why it is so important to conduct clinical trials of malaria treatments in pregnancy.

Martin Tobias discusses a new study that estimates the burden of disease for Mexico as a whole and for each of the country's 32 states.

Emmanuela Gakidou and colleagues find that coverage of cervical cancer screening in developing countries is on average 19% compared to 63% in developed countries.

Stephen Rogerson and Richard Carter discuss two new studies that challenge current dogma by suggesting that vivax malaria can cause severe disease.

Gretchen Stevens and colleagues estimate deaths and loss of healthy life years (measured in disability-adjusted life years, DALYs) for Mexico as a whole and its 32 states.

In a study carried out in Papua New Guinea, Blaise Genton and colleagues show that Plasmodium vivax is associated with severe malaria.

Ric Price and colleagues present data from southern Papua, Indonesia, suggesting that malaria resulting from infection with Plasmodium vivax is associated with substantial morbidity and mortality.

Using defined lipids and purified proteins, Billen et al. offer a new model to reconcile the two currently opposing models for how Bcl-2 family member interactions regulate cell death.

A quantitative, high-temporal resolution study of gene induction in a metabolic pathway reveals an intricate connection between the regulatory architecture and the dynamic response of the system, pointing to possible principles underlying the design of these pathways.